旧网站数据

董世辉，理学博士，兰州大学化学化工学院教授。2006年6月毕业于武汉大学药学院；2011年毕业于中国科学院上海药物研究所新药研究国家重点实验室，获药物化学博士学位，师从岳建民院士。2011?2018年，分别在美国伊利诺伊大学芝加哥分校和厄巴纳-香槟分校从事博士后研究工作，研究方向为具有重要活性和复杂结构天然产物的生物合成途径解析及关键酶功能鉴定。2018年11月，通过兰州大学“萃英特聘教授”人才引进加入化学化工学院、功能有机分子化学国家重点实验室从事教学科研工作。近年来，以第一作者在PNAS、eLife、Chem. Sci.、Cell Chem. Biol.、J. Nat. Prod.等杂志上发表论文十余篇。相关研究成果被多家医药科技媒体转载报道。

实验室地址：化学一号楼3033

实验室网站：NaturalProductDong.CN

研究方向：

1.      新颖结构活性天然产物生物合成的酶学催化机制；

2.      新颖结构活性天然产物的生物合成途径解析；

3.      新颖结构活性天然产物的基因组挖掘及发现。

代表论文(*共同第一作者)：

 (1)    Shi-Hui Dong, Alexey Kulikovsky, Svetlana Dubiley, Konstantin Severinov, and Satish K. Nair. Biosynthesis of the RiPP Trojan Horse Antibiotic Microcin C is Directed by the N-Formyl Peptide Substrate. Chem. Sci. 2019, 10, 2391-2395.

 (2)    Silvia C Bobeica,* Shihui Dong,* Liujie Huo, Nuria Mazo, Martin Irving Harrison McLaughlin, Gonzalo Jiménez-Osés, Satish K Nair, Wilfred A van der Donk. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. 2019, 8, e42305.

 (3)    Wenjia Gu, Shi-Hui Dong, Snigdha Sarkar, Satish K Nair, Eric W Schmidt. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis. Methods in Enzymology 2018, 604, 113-163.

 (4)    Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K Nair, Douglas A Mitchell. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. PNAS 2018, 12, 3030-3035.

 (5)    Matthew C. O’Reilly,* Shihui Dong,* Francis M. Rossi, Kaleigh M. Karlen, Rohan S. Kumar, Satish K. Nair, and Helen E. Blackwell. Non- Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop 'Out' Conformation for LasR. Cell Chem. Biol. 2018, 20, 1128-1139

 (6)    Shi-Hui Dong, Nicole Frane, Quin H. Christensen, E. Peter Greenberg, Rajesh Nagarajan, and Satish K. Nair. Molecular basis for the substrate specificity of quorum signal synthases. PNAS 2017, 114, 9092-9097.

 (7)    Shi-Hui Dong,* Weixin Tang,* Tiit Lukk, Satish K Nair, and Wilfred A van der Donk. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. eLife 2015, DOI: 10.7554/eLife.07607.

 (8)    Weixin Tang,* Shi-Hui Dong,* Lindsay M. Repka, Chang He, Satish K Nair, and Wilfred A van der Donk. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chem. Sci. 2015, 6, 6270-6279.

 (9)    XiangMing Hu, Shi-Hui Dong, Jinjing Chen, Ruichuan Chen, Satish K Nair, Kun Ping Lu, and Lin-Feng Chen. Prolyl isomerase Pin1 regulates the stability, transcriptional activity and oncogenic potential of Brd4. Oncogene 2017 doi:10.1038/onc.2017.137.

(10)    Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E. Cronan, and Satish K. Nair. The Pimeloyl-CoA Synthetase BioW Defines a New Fold for Adenylate-Forming Enzymes. Nat. Chem. Biol. 2017, 13, 668-674.