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兰州大学110周年校庆化学学科系列学术报告第十八场——Zifan Wang 博士

【来源:兰州大学化学化工学院 | 发布日期:2018-11-07 】     【选择字号:

应化学化工学院、功能有机分子化学国家重点实验室邀请,美国蒙大拿大学(University of Montana) Zifan Wang博士来我校进行学术交流并作学术报告,欢迎感兴趣的师生参加

 

报告人:Zifan Wang 博士

    报告题目:Single molecule biophysics and fluorescence correlation spectroscopy

报告时间:20181109日(星期五)下午 16:00

报告地点:第二化学楼101学术报告厅

 

报告人简介

Zifan Wang obtained his B. S. in Chemistry at Lanzhou University in 2007. He received his Ph.D. in Physical/Analytical Chemistry from Wichita State University in 2014 with Prof. Douglas English. Then he joined University of California, Merced as a postdoctoral researcher. From 2017 to present, he was a staff scientist in Core Research Lab at University of Montana.

Abstract

Single molecule biophysics

Proteins work as cellular nanomachines carried out most biological functions, and thus solving the mechanisms of protein folding and binding are a critical component for both theoretical and particle consideration. Atomistic computer simulations have a potential to solve this problem. However, the simulations are based on the imperfect models which need to be assessed and improved in their accuracy. Single-molecule fluorescence spectroscopy method, which provides the stochastic distribution of microscopic pathways, is thus an ideal approach for producing high-resolution experimental information on the distribution of folding transition paths and mechanisms for this protein.

Fluorescence correlation spectroscopy

Catanionic surfactant vesicles form spontaneously from mixtures of single-tailed cationic and anionic surfactants. Hence, they are promising materials for many of the applications currently fulfilled by liposomes including models of biological membranes, drug delivery and solubilizing agents. A new fluorescence correlation spectroscopy (FCS) method is promising as a measurement of the binding constant of a cationic drug /dye molecule with different vesicles formulations at the different pH.