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甘肃省有色金属化学与资源利用重点实验室学术报告——张鹏博士

【来源:兰州大学化学化工学院 | 发布日期:2018-06-11 】     【选择字号:
        应甘肃省有色金属化学与资源利用重点实验室、化学化工学院邀请,美国辛辛那提大学化学系张鹏博士来我校进行学术交流并作学术报告。欢迎广大师生参加。
        报 告 人:张鹏  博士
        报告题目:具有特殊光学性质的纳米颗粒及其在生化检测和生物治疗方面的应用
        报告时间:2018615日(星期五9:00
        报告地点:第二化学楼101报告厅
 
报告人简介:
        在加拿大多伦多大学获得硕士与博士学位,在美国佛罗里达大学从事博士后研究。在美能源部国家再生能源实验室从事短暂研究后,成为新墨西哥理工学院的助理教授及副教授。现为辛辛那提大学化学系副教授。研究方向包括合成不同纳米材料用于生化检测和生物治疗的应用,表面增强拉曼光谱及能量上转换方面的研究。现已在国际期刊发表85篇论文,有6项专利。
报告摘要
  Nanoscience is at the unexplored frontiers of science and engineering, and it offers one of the most exciting opportunities for innovation in technology. One of the hopes for nanoscience and technology is that the combination of a number of areas – from physics and chemistry to material science and biology – will create a new area and lead to major advances both in understanding of science and in their applications in technology. The central theme of my research program covers a variety of topics at the Chem/Bio/Energy interface.
Sensing applications of photon upconversion nanoparticles
  Phosphor/fluorescent molecules/particles have been widely used in various applications for quite some time. Typically, light with longer wavelength(s) is emitted when excited by shorter wavelength light, a process called down-conversion. The opposite effect also exists, where a phosphor particle is excited with an infrared or red light and emits color(s) of shorter wavelengths, a process called up-conversion. Photon upconversion materials convert lower-energy light to higher-energy light, which is realized through excitation with multiple photons. Materials with upconversion properties are much less common than their down-converting counterparts. Because most non-target materials in a complex mixture do not possess such upconversion properties, a dramatically enhanced S/N ratio is expected in sensing and luminescence reporting applications. Photon upconversion materials also do not suffer from photobleaching. This makes them ideal for sensing applications. In this presentation, I will briefly discuss the synthesis, characterization and some sensing applications based on these photon upconversion nanoparticles. The results demonstrate great potential of such nanomaterials in bio-related applications.
Nanoparticle-based photosensitizers for photodynamic inactivation of bacteria and cancer cells
  Singlet oxygen plays a critical role in a large number of applications including photodynamic therapy of cancers, photodynamic inactivation of microorganisms, photooxidation, and photodegradation of polymers. We report a general strategy to improve singlet oxygen production via resonance coupling between surface plasmon of nanoparticles and photosensitizing molecules. The resulting hybrid photosensitizers have demonstrated markedly enhanced singlet oxygen production under both visible light and near-infrared light excitations even for those photosensitizing molecules without near-infrared absorption, as compared to the free photosensitizing molecules of the same concentration. Subsequently, they have shown exceptionally high photoinactivation efficiency against both Gram-positive and Gram-negative bacteria, including the drug-resistant strains, and cancer cells under a wide range of excitations, including the near-infrared light. The results offer a platform to develop more effective and efficient hybrid photosensitizers for broad-spectrum photodynamic therapy.