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魏华(教授)★

【来源:兰州大学化学化工学院 | 发布日期:2016-12-08 】     【选择字号:
姓  名
魏华
所属部门
高分子化学与物理
职  称
教授
导师类别
博士生导师
研究方向
医用、药用高分子
联系方式

魏华教授(Professor Hua Wei,博士生导师。男,19822月生。20046月在武汉大学化学与分子科学学院化学基地班专业获理学学士学位,并于20039月-20046月赴中国科学院长春应用化学研究所高分子物理与化学国家重点实验室交流,完成本科毕业设计(导师:姬相玲研究员),20049月-20096月在武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室高分子化学与物理专业获理学博士学位(导师:卓仁禧院士和张先正教授)。博士毕业后于20102月-20118月在悉尼大学化学与生物分子工程系从事博士后研究(合作导师:Fariba Dehghani教授),同时与悉尼大学化学系聚合物与胶体重点实验室(Key Centre for Polymer and Colloids KCPC)主任S?bastien Perrier 教授开展合作研究。20119月-20148月在美国西雅图华盛顿大学生物工程系任高级研究员(合作导师:Suzie H. Pun教授)。20149月全职回国工作。曾获三星奖学金,宝钢优秀学生特等奖学金,2010年湖北省优秀博士论文,2011年全国优秀博士论文提名奖,和悉尼大学博士后奖学金等荣誉。20155月入选第十一批千人计划“青年千人”。研究兴趣主要集中在高分子化学和生物医用高分子材料,如利用可控聚合设计和制备智能药物、基因载体材料,并通过体外细胞实验和体内动物实验评价其疗效。

主持科研项目

1. 第十一批千人计划“青年千人”。

2. 国家自然科学基金面上项目“新型花形聚合物前药载体的设计、合成及其肿瘤靶向性能研究”,项目号51473072

3. 国家自然科学基金青年基金“新型还原敏感性星形阳离子共聚物的设计、合成及其作为非病毒基因载体在体外和体内转染效果的研究”,项目号21504035

代表性科研论文 (2012-)

以兰州大学为第一单位和通讯作者发表论文

1. Tu XY, Meng C, Wang YF, Ma LW, Wang BY, He JL, Ni PH, Ji XL, Liu MZ, Wei H*. Fabrication of thermo-sensitive cyclic brush copolymer with enhanced therapeutic efficacy for anticancer drug delivery. Macromolecular Rapid Communications (IF: 4.265, in press, accepted on 12/08/2017)

2. Zuo C, Peng JL, Cong Y, Dai XY, Zhang XL, Zhao SJ, Zhang XS, Ma LW, Wang BY, Wei H*. Fabrication of supramolecular star-shaped amphiphilic copolymers for ROS-triggered drug release. Journal of Colloid and Interface Science (IF: 4.233, in press, DOI: https://doi.org/10.1016/j.jcis.2017.12.022)

3. Zheng LP, Wang YF, Zhang XS, Ma LW, Wang BY, Ji XL, Wei H*. Fabrication of hyperbranched block-statistical copolymer-based prodrug with dual sensitivities for controlled release. Bioconjugate Chemistry (IF: 4.818, in press, DOI: 10.1021/acs.bioconjchem.7b00699)

4. Tu XY, Meng C, Liu Z, Sun L, Zhang XS, Zhang MK, Sun MR, Ma LW, Liu MZ, Wei H*. Synthesis and phase transition of poly(N-isopropylacrylamide)-based thermo-sensitive cyclic brush polymer. Polymers 2017, 9, 301. (IF: 3.364)

5. Zhou XF, Chang C, Zhou Y, Sun L, Xiang H, Zhao SJ, Ma LW, Zheng GH, Liu MZ, Wei H*. A comparison study to investigate the effect of the drug-loading site on its delivey efficacy using double hydrophilic block copolymer-based prodrugs. Journal of Materials Chemistry B 2017, 5, 4443-4454. (IF: 4.543, selected as Journal of Materials Chemistry B Emerging Investigators 2017 and Back Cover)

6. Sun L, Zhou Y, Zhou XF, Fu Q, Zhao SJ, Tu XY, Zhang XL, Ma LW, Liu MZ, Wei H*. Dual transitions of toothbrush-like double hydrophilic block copolymers. Polymer Chemistry 2017, 8, 500-504. (IF: 5.375)

7. Zhao SJ, Yang HR, Zuo C, Sun L, Ma LW, Wei H*. pH-sensitive drug release of star-shaped micelles with OEG brush corona. RSC Advances 2016, 6, 111217-111225. (IF: 3.108)

8. Zuo C, Dai XY, Zhao SJ, Liu XN, Ding SL, Ma LW, Liu MZ, Wei H*. Fabrication of dual-redox responsive supramolecular copolymers using a reducible β-cyclodextran-ferrocene double-head unit. ACS Macro Letters 2016, 5, 873-878. (IF: 6.185)

9. Tu XY, Liu MZ, Wei H*. Recent progress on cyclic polymers: synthesis, bioproperties, and biomedical applications. Journal of Polymer Science Part A: Polymer Chemistry 2016, 54, 1447-1458. (IF: 2.952, invited review)

10. Wei H*, Yu CY. Cyclodextrin-functionalized polymers as drug carriers for cancer therapy. Biomaterials Science 2015, 3, 1050-1060. (IF: 4.210, invited review)

加入兰州大学前发表论文

11. Wang CE, Wei H (共同第一作者), Tan N, Boydston AJ, Pun SH. Sunflower polymers for folate-mediated drug delivery. Biomacromolecules 2016, 17, 69-75. (IF: 5.246)

12. Wei H, Pun SH. Double-head agents: A powerful tool for synthesizing functional biomaterials. Material Matters 2015, 10, 11-14. (Invited review)

13. Wei H, Wang CE, Tan N, Boydston AJ, Pun SH. ATRP synthesis of sunflower polymers using cyclic multimacroinitiators. ACS Macro Letters 2015, 4, 938-941. (IF: 6.185)

14. Wei H, Zhuo RX, Zhang XZ. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Progress in Polymer Science 2013, 38, 503-535. (IF: 25.766)

15. Wei H, Chu DSH, Zhao J, Pahang JA, Pun SH. Synthesis and evaluation of cyclic cationic polymers for nucleic acid delivery. ACS Macro Letters 2013, 2, 1047-1050. (IF: 6.185)

16. Wei H, Volpatti LR, Sellers DL, Maris DO, Andrews IW, Hemphill AS, Chan LW, Chu DSH, Horner PJ, Pun SH. Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie International Edition 2013, 52, 5377-5381. (IF: 11.994, selected as Very Important Paper (VIP))

17. Wei H, Pahang JA, Pun SH. Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules 2013, 14, 275-284. (IF: 5.246)

18. Wei H, Schellinger JG, Chu DSH, Pun SH. Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. Journal of the American Chemical Society 2012, 134, 16554-16557. (IF: 13.858)