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肖建喜(教授)★

【来源:兰州大学化学化工学院 | 发布日期:2016-12-08 】     【选择字号:

 

姓  名
 肖建喜
所属部门
分析化学
职  称
教授
导师类别
博士生导师
研究方向
  生物分析化学,蛋白质自组装,结构与功能
联系方式
                    xiaojx@lzu.edu.cn

 肖建喜,男,198012月生,兰州大学化学化工学院教授,博士生导师。兰州大学萃英人才建设计划引进人才,中国分析测试协会青年学术委员会委员,甘肃省化学会青年学术委员会委员。2003年获武汉大学化学学士学位,2009年获美国新泽西州罗格斯大学(Rutgers-New Brunswick)化学博士学位。2009-2011年在罗格斯大学从事博士后研究工作。201212月获聘为兰州大学教授。目前主持萃英人才建设计划科研启动基金,国家自然科学青年基金,功能有机分子化学国家重点实验室开放基金等多个项目。主要研究领域包括胶原蛋白的结构和功能,胶原蛋白自组装的分子机制及在生物材料中的应用,肿瘤的早期检测方法以及便携式检测设备。在Journal of the American Chemical Society, Chemical Communications, Chemistry-A European Journal, Journal of Biological Chemistry, Journal of Materials Chemistry B等国际知名期刊发表论文20余篇。论文成果多次被评为热点论文,并被ChemistryViews等国际专业媒体报道。指导本科生团队荣获川沙新镇杯首届全国智慧人才创业大赛二等奖。

    非常欢迎热爱科研的化学,医学,药学,生物学的研究生和本科生加入我们。

代表性论文:

1)        M. He, Y. Zhang, J. Munyemana, T. Wu, Z. YangH. Chen, W. Qu, and J. Xiao*. Tuning the hierarrchical nanostructure of hematite mesocrystals by collagen-templated biomineralization. Journal of Materials Chemistry B, 2017, 5, 1423 – 1429.

2)        M. He, L. Wang, J. Wu and J. Xiao*. Ln3+-Mediated Self-Assembly of a Collagen Peptide into Luminescent Banded Helical Nanoropes. Chemistry - A European Journal, 2016, 22, 1914-1917. (Hot paper, Highlighted by ChemistryViews Magazine)

3)        X. Sun, J. Fan, W. Ye, H. Zhang, Y. Cong and J. Xiao*. A Highly Specific Graphene Platform for Sensing Collagen Triple Helix. Journal of Materials Chemistry B, 2016, 4, 1064-1069. (Hot paper)

4)        X. Cai, Q. Yang, J. Ding, W. Ye, X. Li, and J. Xiao*. Paper-based FRET for direct detection of collagen triple helix. Journal of Materials Chemistry B, 2016, 4, 7009-7013.

5)        X. Sun, J. Fan, X. Li, S. Zhang, X. Liu and J. Xiao*. Colorimetric and Fluorometric Monitoring of the Helix Composition of Collagen Peptides at nM level. Chemical Communications, 2016, 52, 3107-3110. (Highlighted by X-MOL)

6)        X. Sun, J. Fan, Y. Zhang, H. Chen, Y. Zhao and J. Xiao*. A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments. Biosensors and Bioelectronics, 2016, 79, 15-21.

7)        X. Sun, Y. Chai, Q. Wang, H. Liu, S. Wang, and J. Xiao*. A natural interruption displays higher global stability and local conformational flexibility than a similar Gly mutation sequence in collagen mimic peptides. Biochemistry, 2015, 54, 6106-6113.

8)        J. Xiao, X. Sun, M. Balaram, B. Brodsky and J. Baum. NMR Studies Demonstrate a Unique AAB Composition and Chain Register for a Heterotrimeric Type IV Collagen Model Peptide Containing a Natural Interruption Site. Journal of Biological Chemistry, 2015, 90, 24201-24209.

9)        J. Xiao, H. Cheng, T. Silva, J. Baum, and B. Brodsky. Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site. Biochemistry, 2011, 50, 10771.

10)    J. Xiao, M. Balaraman, Y Li, B. Brodsky and J. Baum. Osteogenesis imperfecta model peptides: incorporation of residues replacing Gly within a triple helix achieved by renucleation and local flexibility. Biophysical Journal, 2011, 101, 449.

11)    J. Xiao, R.M. Addabbo, J.L. Lauer, G.B. Fields, and J. Baum. Local conformation and dynamics of isoleucine in the collagenase cleavage site provides recognition signal for matrix metalloproteinases. Journal of Biological Chemistry, 2010, 285, 34181.

12)    J. Xiao and J. Baum. Structural insights from 15N relaxation data for an anisotropic collagen peptide. Journal of the American Chemical Society, 2009, 131, 18194.

13)    M. Balaraman, J. Xiao, G. Thiagarajan, J. Baum and B. Brodsky. NMR monitoring of chain-specific stability in heterotrimeric collagen peptides. Journal of the American Chemical Society 2008, 130, 13520.