联系方式

职  称:教授

所在部门:生命分析化学与原子分子工程研究所

研究方向:生物分析化学、生物医用材料、蛋白质化学

办 公 室 :311

联系电话:

电子邮件:xiaojx@lzu.edu.cn

肖建喜教授、博士生导师。1980年12月生,2003年获武汉大学化学学士学位,2009年获美国新泽西州罗格斯大学(Rutgers-New Brunswick)化学博士学位。2009-2011年在罗格斯大学从事博士后研究工作。2012年获聘为兰州大学教授。兰州大学“萃英人才建设计划”引进人才,甘肃省陇原青年创新创业人才,享受甘肃省高层次专业技术人才津贴。中国分析测试协会青年学术委员会委员,甘肃省化学会青年学术委员会委员。国际蛋白质专业期刊Protein & Peptide Letters编委。主要研究领域包括生物分析化学,生物医用材料,蛋白质化学,蛋白质工程,胶原蛋白的结构、功能、疾病机理与产业化应用等。

目前主持国家自然科学基金面上项目、甘肃省、兰州市和横向项目多项。在Journal of the American Chemical Society, Chemical Communications, Chemistry-A European Journal, Biosensors and Bioelectronics, Journal of Materials Chemistry B, Journal of Biological Chemistry等国际知名期刊发表胶原蛋白相关论文30余篇。研究成果多次被评为封面论文,并被ChemistryViews 等国际专业媒体专门报道。申请发明专利20余项。

近5年代表性论文(Representative Publications):

(1) X. Sun, L. Yao, C. Fu, L. Luo, J. Wang, and J. Xiao. Detection of target collagen peptides with single amino acid mutation using two fluorescent peptide probes. Journal of Materials Chemistry B, 2019,7, 7676-7682 (Cover paper).

(2) L. Yao, Z. Liu, J. Yu, L. Luo, J. Wang, and J. Xiao. Morphology of osteogenesis imperfecta collagen mimetic peptide assemblies correlates with the identity of glycine substituting residue. ChemBioChem, 2019, 20, 3013-3019 (Cover paper).

(3) X. Sun, Z. Liu, S. Zhao, X. Xu, S. Wang, C. Guo and J. Xiao. A self-assembling collagen mimetic peptide system to simultaneously characterize the effects of osteogenesis imperfecta mutations on conformation, assembly and activity. Journal of Materials Chemistry B, 2019, 7, 3201-3209 (Cover paper).

(4) X. Cai, Z. Liu, S. Zhao, C. Song, S. Dong and J. Xiao. A single stranded fluorescent peptide probe for targeting collagen in connective tissues. Chemical Communications, 2017, 53, 11905-11908.

(5) M. He, Y. Zhang, J. Munyemana, T. Wu, Z. Yang, H. Chen, W. Qu, and J. Xiao. Tuning the hierarrchical nanostructure of hematite mesocrystals by collagen-templated biomineralization. Journal of Materials Chemistry B, 2017, 5, 1423-1429.

(6) X. Cai, Q. Yang, J. Ding, W. Ye, X. Li, and J. Xiao. Paper-based FRET for direct detection of collagen triple helix. Journal of Materials Chemistry B, 2016, 4, 7009-7013.

(7) M. He, L. Wang, J. Wu and J. Xiao. Ln3+-Mediated Self-Assembly of a Collagen Peptide into Luminescent Banded Helical Nanoropes. Chemistry - A European Journal, 2016, 22, 1914-1917 (Hot paper).

(8) X. Sun, J. Fan, W. Ye, H. Zhang, Y. Cong and J. Xiao. A Highly Specific Graphene Platform for Sensing Collagen Triple Helix. Journal of Materials Chemistry B, 2016, 4, 1064-1069. (Hot paper)

(9) X. Sun, J. Fan, X. Li, S. Zhang, X. Liu and J. Xiao. Colorimetric and Fluorometric Monitoring of the Helix Composition of Collagen Peptides at nM level. Chemical Communications, 2016, 52, 3107-3110. 

(10 )X. Sun, J. Fan, Y. Zhang, H. Chen, Y. Zhao and J. Xiao. A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments. Biosensors and Bioelectronics, 2016, 79, 15-21.


讲授本科生课程《仪器分析》和博士生课程《高等光谱分析》。指导本科生国创、䇹政等项目10余项,被评为第四届中国“互联网+”大学生创新创业大赛国家级优秀创新创业导师。