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职  称:教授

所在部门:有机化学第一研究所

研究方向:有机与天然产物分析;核磁共振方法学; 环肽化学生物学

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联系电话:

电子邮件:leixx@lzu.edu.cn

雷新响,药物化学专业,博士,三级教授,毕业于中国科学院成都生物研究所,曾在耶鲁大学从事研究工作。现就职于兰州大学化学化工学院、功能有机分子化学国家重点实验室。从事基于核磁共振波谱技术的药物分析、天然产物结构鉴定、活性筛选等研究工作。任Magn. Reson. Chem.国际编委;Natur. Prod. & Bioprosp编委;Magn. Reson. Lett. 等编委。组织了两次国际学术会议,在全国性和国际性学术会议上做报告20余次。现任中国化学会有机分析化学专业委员会委员,湖北省药学会理事,湖北省晶体学会理事。

主持国家基金面上及国际合作项目多项,曾主持湖北省杰青项目

1. Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents. Lin, Yuexiao; Li, Jiaqian; Qin, Si-Yong; Sun, Han; Yang, Yan-Ling; Navarro-Vazquez, Armando; Lei, Xinxiang* Chemical Science, 2022, 13, 5838-5845. Chem Sci Pick of Week, Hot Article Collection, inside back cover.

2. Peptide probes with high affinity to target protein selection by phage display and characterization using biophysical approaches. Yang, Xiao-Qin; Bai, Li-Wen; Chen, Yu; Lin, Yue-Xiao; Xiang, Hua; Xiang, Ting-Ting; Zhu, Shuang-Xing; Zhou, Li; Li, Kai*; Lei, Xinxiang* New J. Chem., 2022, 46, 10299-10307.

3. Ti3C2Tx MXene Liquid Crystal: Access to Create Background-Free and Easy-Made Alignment Medium. Zhao, You; Yu, Qinghua; Cheng, Wei-Wei; Li, Jia-Qian; Zhang, Ai-Qing; Lei, Xinxiang*; Yang, Yingkui; Qin, Si-Yong * ACS Nano, 2022, 16, 5454-5462.

4. Structural Elucidation of Garcipaucinones A and B From Garcinia paucinervis Using Quantum Chemical Calculations. Tan, Xue; Han, Xiaoyang; Teng, Haida; Li, Qingqing; Chen, Yu; Lei, Xinxiang*; Yang, Guangzhong* J. Nat. Prod., 2021, 84, 972–978.

5. Solvent-tailored ordered self-assembly of oligopeptide amphiphiles to create an anisotropic meso-matrix. Jiang, Yan; Zhao, You; Zhang, Ai-Qing; Lei, Xinxiang*; Qin, Si-Yong* Chem. Commun., 2021, 57, 6181-6184.

6. Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems using a Liquid Crystalline based Medium. Qin, Si-Yong*; Jiang, Yan; Sun, Han; Liu, Han; Zhang, Ai-Qing; Lei, Xinxiang* Angew. Chem. Int. Ed., 2020, 59, 17097-17103. Hot Paper.

7. Enantioselective Pd-Catalyzed Hydrofluorination of Vinylarenes. Yin, Xuemei; Chen, Bin; Qiu, Feng; Wang, Xihong; Liao, Yang; Wang, Min; Lei, Xinxiang*; Liao, Jian* ACS Catal., 2020, 10, 1954−1960.

8. Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. Li, Xiao-Lu; Chi, Lu-Ping; Navarro-Vazquez, Armando; Hwang, Songhwan; Schmieder, Peter; Li, Xiao-Ming; Li, Xin; Yang, Sui-Qun; Lei, Xinxiang*; Wang, Bin-Gui*; Sun, Han* J. Am. Chem. Soc., 2020, 142, 2301−2309.  

9. Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules. Liu, Han; Chen, Pian; Li, Xiao-Lu; Sun, Han; Lei, Xinxiang* Magn. Reson. Chem., 2020, 58,404-410.

10. Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species. Han, Wen-Bo; Wang, Guang-Yi; Tang, Jiang-Jiang; Wang, Wen-Ji; Liu, Han; Gil, Roberto R.; Navarro-Vazquez, Armando; Lei, Xinxiang*; Gao, Jin-Ming*, Org. Lett., 2020, 22, 405−409. 

11. Directing an oligopeptide amphiphile into an aligned nanofiber matrix for elucidating molecular structures. Qin, Si-Yong*; Ding, Wen-Qiang; Jiang, Zhi-Wei; Lei, Xinxiang*; Zhang, Ai-Qing*, Chem. Commun., 2019, 55, 1659-1662.

12. Enantiomeric NMR discrimination of carboxylic acids using actinomycin D as a chiral solvating agent. Bai, Liwen; Chen, Pian; Xiang, Jiangxia; Sun, Jiarui; Lei, Xinxiang*, Org. Biomol. Chem., 2019, 17, 1466-1470.

13. Residual Dipolar Couplings in Structure Determination of Natural Products. Li, Gao-Wei; Liu, Han; Qiu, Feng; Wang, Xiao-Juan; Lei, Xin-Xiang*, Natur. Prod. & Bioprosp., 2018, 8, 279-295.

14. A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol. Lei, Xinxiang*; Qiu, Feng; Sun, Han; Bai, Liwen; Wang, Wen-Xuan; Xiang, Wensheng; Xiao, Hongping, Angew. Chem. Int. Ed., 2017, 56, 12857-12861.

15. Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Li, Gao-Wei; Cao, Jiang-Ming; Zong, Wen; Hu, Li; Hu, Mao-Lin; Lei, Xinxiang*; Sun, Han*; Tan, Ren Xiang*, Chem. Eur. J., 2017, 23, 7653-7656.

16. An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Zong, Wen; Li, Gao-Wei; Cao, Jiang-Ming; Lei, Xinxiang*; Hu, Mao-Lin; Sun, Han*; Griesinger, Christian; Tan, Ren Xiang*, Angew. Chem. Int. Ed., 2016, 55, 3690-3693.

17. Enantiodiscrimination of carboxylic acids using the diphenylprolinol NMR chiral solvating agents. Li, Gaowei; Cao, Jiangming; Zong, Wen; Lei, Xinxiang*; Tan, Renxiang*, Org. Chem. Front., 2016, 3, 96-102.

18. Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. Lei, Xinxiang*; Xu, Zhen; Sun, Han; Wang, Shun; Griesinger, Christian; Peng, Li; Gao, Chao*; Tan, Ren X*. J. Am. Chem. Soc., 2014, 136, 11280-11283.

19. A Novel Amine Receptor Based on the Binol Scaffold Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids. Ma, Qingzhu; Ma, Minshan; Tian, Hongying; Ye, Xiaoxia; Xiao, Hongping; Chen, Lian-hui*; Lei, Xinxiang*, Org. Lett., 2012, 14, 5813-5815.

20. Determinants of mRNA recognition and translation regulation by Lin28. Lei, Xin-Xiang; Xu, Jie; Ma, Wei; Qiao, Chong; Newman, Martin A.; Hammond, Scott M.; Huang, Yingqun*, Nucleic Acids Res., 2012, 40, 3574-3584.


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